ACCIDENTAL EXPOSURE INFORMATION

The purpose of this section is to supply the user of our biological products with pertinent information concerning the product and any medical information known about the biologic.

Recommendation to contact your physician is always warranted. Products do not contain live organisms or toxins UNLESS otherwise noted and additional instructions or information are given. Local swelling and inflammation at the injection site is possible from vaccines and/or from contaminated equipment (used or dirty needles). Secondary infections are therefore possible from contaminated equipment and a physician should consider prophylactic broad spectrum antibiotics in most cases.

Anthrax Spore Vaccine (Bacillus anthracis) (Attenuated Live Bacterial Product)

  • Contains non-pathogenic, non-encapsulated, live and variant strain of Bacillus anthracis.
  • This variant is the Sterne Strain, an avirulent, gram positive, spore forming micro-organism. Because anthrax contains live bacterial spores and saponin adjuvant, localized swelling and inflammation are possible at the injection site.
  • The vaccine will not cause Anthrax disease. Contact your physician. Anthrax spore vaccine contains live bacterial spores. Local swelling at the injection site is possible from the vaccine or from contaminated equipment. A physician should consider a broad spectrum antibiotic for secondary infections caused by contaminated equipment.

Bluetongue Vaccine –Type 10 (Modified Live Viral Vaccines- No Adjuvant) (Avirulent)

  • Contains trace amounts of penicillin and streptomycin as preservatives.

Bovi-Sera (Arcanobacterium Pyogenes- Escherichia Coli- Mannheimia Haemolytica- Pasteurella Multocida- Salmonella Typhimurium Antibody) (Bovine Origin Serum Product)

  • Contains thimerosal and phenol as preservatives.
  • Some individuals can be allergic to bovine serum proteins and an allergic reaction is possible.

BVD (Bovine Virus Diarrhea) (Modified Live Virus)

  • Contains trace amounts of penicillin and streptomycin as preservatives.

Brucella Abortus Strain RB-51 (Attenuated Live Bacterial Product)

  • Contains a mutant rough form of the parent organism. This product does not appear to cause undulant fever in people, but the lack of sufficient data precludes this definitively.
  • In vivo studies in test animals, demonstrate growth of the organism at injection site and regional lymph nodes.
  • Contact your physician. The above product (Brucella Abortus) contains live bacterial organisms. Local swelling at the injection site is possible from the bacterin or from contaminated equipment. The organism is resistant to Penicillin and Rifampin. CDC recommends the physician prescribe 100mg doxycycline BID x 21days for exposure to this organism. (See the end of page for reference material regarding Brucella abortus.)

The following is reference material regarding exposure to Brucella. The Center for Disease Control also has these articles on the website:

(Excerpt from paper: Gerhardt GG, Roop RM, Bagchi T, Boyle S, Buhrman D, and Sriranganathan N. Biological properties of RB51; a stable rough strain of Brucella abortus. Veterinary Microbiology, 28 (1991), 171-188. States: RB-51 strain was susceptible to: crythromycin, ampicillin, chloramphenicol, gentamycin, kanamycin, neomycin, oxytetracycline, carbenicillin, cephalothin, streptomycin, nitrofurantoin, tetracycline and trimethoprim/sulfamethoxazole. Resistant to: triple sulfa, penicillin, furazolidone, rifampin.

Excerpt from paper: J. Vet Pharmacol. Therap. 28, 185-201, 2005, entitled: Veterinary pharmacovigilance. Part 4. Adverse reactions in humans to veterinary medicinal products. (The 26 subjects referenced below contacted Colorado Serum Company initially, during the first year of RB-51 usage, and we forwarded on to CDC for their surveillance study): A recent study reported on humans exposed to Brucella abortus strain RB-51 via vaccination. The Centers for Disease Control (CDC) in the US conducted passive surveillance for accidental injection with exposure to the vaccine and received reports from 26 affected individuals (via Colorado Serum Company). Of these, 21 subjects had suffered needle stick injuries, while four had received conjunctival spray exposure and one an exposure to an open wound. There were no clear cases of brucellosis in these individuals, suggesting that this strain might have low pathogenicity to humans but at present, there is insufficient data to determine if the strain can cause systemic brucellosis in humans.” (Ashford et al., 2004)

Campylobacter Fetus Bacterin- Bovine (Killed Bacterial Products w/Oil Adjuvant)

  • Contains thimerosal as a preservative.

Campylobacter Fetus Bacterin- Ovine (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Caseous D-T (Clostridium Tetani-Perfringens Type D-Corynebacterium Pseudotuberculosis Bacterin-Toxoid) (Killed Bacterial and Bacterial Toxoid Products w/ Ammonium Alum Adjuvant)

  • Contains thimerosal as a preservative.

Caprine Serum Fraction, Immunomodulator (Caprine Origin Serum Products)

  • Some individuals can be allergic to caprine serum proteins and an allergic reaction is possible.

Case-Bac (Corynebacterium Pseudotuberculosis Bacterin-Toxoid) (Killed Bacterial and Bacterial Toxoid Products w/Ammonium Alum Adjuvant)

  • Contains thimerosal as a preservative.
  • A detoxified and purified whole culture of Corynebacterium pseudotuberculosis.

Chlamydia Psittaci Bacterin (Killed Bacterial Products w/Oil Adjuvant)

  • Contains trace amounts of penicillin and streptomycin as preservatives.

Clostridium Chauvoei-Septicum- Essential 2 (Double Bacterin) (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Clostridium Chauvoei-Septicum-Mannheimia Haemolytica-Pasteurella Multocida- Essential 2+P (Triple Bacterin) (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Clostridium Chauvoei-Septicum-Novyi-Sordellii Bacterin-Toxoid- Essential 4 (CSNS) (Killed Bacterial Product w/Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Clostridium Haemolyticum Bacterin- Essential 1 (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Clostridium Perfringens Type C Antitoxin (Equine Origin Serum Product)

  • Some individuals can be allergic to equine serum proteins and an allergic reaction is possible.

Clostridium Perfringens Type C and D Antitoxin (Equine Origin Serum Product)

  • Contains phenol and thimerosal as preservatives.
  • Some individuals can be allergic to equine serum proteins and an allergic reaction is possible.

Clostridium Perfringens Type C and D Tetanus Toxoid- Essential 3+T (Detoxified Toxins with Ammonium Alum (NH4 Alum) and Potassium Alum (K Alum)

  • Contains thimerosal as a preservative.

Clostridium Perfringens Type C and D Toxoid- Essential 3 (Detoxified Toxins with Ammonium Alum (NH4 Alum)

  • Contains thimerosal as a preservative.

Encephalomyelitis Vaccine- Eastern and Western (Killed Viral Vaccines w/ Ammonium Alum (NH4 Alum).

  • Contains thimerosal and trace amounts of penicillin and streptomycin as preservatives.

Encephalomyelitis Vaccine- Eastern and Western –Tetanus Toxoid (Killed Viral Vaccines w/ Ammonium Alum (NH4 Alum).

  • Contains thimerosal and trace amounts of penicillin and streptomycin as preservatives.

IBR Vaccine- Respira 1 (Modified Live Viral Vaccines- No Adjuvant) (Avirulent).

  • Contains trace amounts of penicillin and streptomycin as preservatives.

IBR-BVD-PI3 Vaccine- Respira 3 (Modified Live Viral Vaccines- No Adjuvant) (Avirulent).

  • Contains trace amounts of penicillin and streptomycin as preservatives.

IBR-BVD-PI3-Lepto5 Vaccine- Respira 3 (Modified Live Viral Vaccines/Killed Bacterin).

  • Contains thimerosal and trace amounts of penicillin and streptomycin as preservatives.

IBR- Lepto 5- Pre Breed 6 (Modified Live Virus/Killed Bacterin)

  • Contains thimerosal and trace amounts of penicillin and streptomycin as preservatives.

Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (Lepto 5) (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Mannheimia Haemolytica-Pasteurella Multocida Bacterin (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Normal Equine Serum (Equine Origin Serum Products)

  • Contains phenol and thimerosal as preservatives.
  • Some individuals can be allergic to equine serum proteins and an allergic reaction is possible.

Ovine Ecthyma Vaccine (Live Viral Vaccine- No Adjuvant).

  • Contains trace amounts of penicillin and streptomycin as preservatives.
  • Prompt washing of exposed area with a disinfectant and prompt medical attention is advised.
  • This can cause human skin lesions similar to those in sheep.

Pulmo Clear (Caprine Serum Fraction, Immunomodulator)

  • Contains phenol and thimerosal as preservatives.

Ram Epididymitis Bacterin (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Respiragen (Arcanobacterium Pyogens- Mannheimia Haemolytica- Pasteurella Multocida (Bovine Origin Serum Products)

  • Contains thimerosal and phenol as preservatives.
  • Some individuals can be allergic to bovine serum proteins and an allergic reaction is possible.

Salmonella Dublin-Typhimurium Bacterin (Killed Bacterial Product w/ Aluminum Hydroxide (AL OH) Adjuvant)

  • Contains thimerosal as a preservative.

Tetanus Antitoxin (Equine Origin Serum Products)

  • Contains phenol and thimerosal as preservatives.
  • Some individuals can be allergic to equine serum proteins and an allergic reaction is possible.

Tetanus Toxoid, Concentrated/Adjuvanted (Detoxified Toxins with Potassium Alum (K Alum))

  • Contains thimerosal as a preservative.

Tetanus Toxoid, Unconcentrated/Adjuvanted (Detoxified Toxins with Potassium Alum (K Alum))

  • Contains thimerosal as a preservative.

Wart Vaccine (Killed Viral Vaccine, No Adjuvant)

West Nile Virus Antibody (Equine Origin Serum Product)

  • Contains thimerosal as a preservative.
  • Some individuals can be allergic to equine serum proteins and an allergic reaction is possible.

Recommendation to contact your physician is always warranted. Products do not contain live organisms or toxins UNLESS otherwise noted and additional instructions are given. Local swelling and inflammation at the injection site is possible from vaccines and/or from contaminated equipment (used and/or dirty needles). Secondary infections are therefore possible from contaminated equipment and a physician should consider prophylactic broad spectrum antibiotics in most cases.